In a new Value Blueprints research brief, IVI explores the concept of “structural uncertainty,” an important source of uncertainty that is not generally measured or addressed in cost-effectiveness models. In this research brief, we use the IVI-RA model to demonstrate how different structural assumptions lead to varying cost-effectiveness estimates. As our findings make clear, it is important that model-based cost-effectiveness analyses explicitly incorporate and report effects of structural uncertainty to ensure that real-world decision makers have full information. Read the full press release here.